منابع مشابه
Systems biology and innate immunity.
use of systems biology approaches to better understand innate immunity. Inflammatory disorders or syndromes are readily amenable to investigation by systems biology approaches, largely because an extensive repertoire of antibodies, reagents and assays exists for the evaluation of inflammatory cells and molecules. Moreover, inflammatory disorders often have systemic sequelae such as changes in a...
متن کاملSystems biology of innate immunity.
Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes. These endeavors, collectively referred to as systems biology establish a paradigm by which to systematically interrogate, model, and itera...
متن کاملStructural biology of innate immunity.
Innate immune responses depend on timely recognition of pathogenic or danger signals by multiple cell surface or cytoplasmic receptors and transmission of signals for proper counteractions through adaptor and effector molecules. At the forefront of innate immunity are four major signaling pathways, including those elicited by Toll-like receptors, RIG-I-like receptors, inflammasomes, or cGAS, ea...
متن کاملInnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation
InnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes. In this article, we provide details of recent updates and improvements to the database. InnateDB now contains >196 000 human, mouse and bovine experimentally validated molecular interactions and ...
متن کاملEnabling a systems biology approach to immunology: focus on innate immunity.
Immunity is not simply the product of a series of discrete linear signalling pathways; rather it is comprised of a complex set of integrated responses arising from a dynamic network of thousands of molecules subject to multiple influences. Its behaviour often cannot be explained or predicted solely by examining its components. Here, we review recently developed resources for the systems-level i...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2013
ISSN: 1662-8128,1662-811X
DOI: 10.1159/000347135